Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
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چکیده
منابع مشابه
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
Activation of inflammation in white adipose tissue (WAT), includes infiltration/expansion of WAT macrophages, contributes pathogenesis of obesity, insulin resistance, and metabolic syndrome. The inflammasome comprises an intracellular sensor (NLR), caspase-1 and the adaptor ASC. Inflammasome activation leads to maturation of caspase-1 and processing of IL1β, contributing to many metabolic disor...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep28056